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ORTHOPAK®

NON-INVASIVE BONE GROWTH STIMULATOR

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When a patient presents with a clinical long bone nonunion, an electrical bone growth stimulator like the Biomet OrthoPak Non-invasive Bone Growth Stimulator System is a proven, adjunctive solution to aid in their healing process.

 

The OrthoPak is an innovative, small, lightweight, easy-to-use, non-invasive, FDA approved bone growth stimulation device that helps aid in the healing of fracture nonunions. Its lightweight electrodes weigh less than an ounce, allowing for minimal weight around either side of the fracture nonunion site that can be comfortably worn under a brace.

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The OrthoPak is powered by capacitive coupling (CC) electrical stimulation technology with proven pre-clinical results and an established clinical safety and efficacy profile. The OrthoPak has been safely and effectively helping people heal for 38 years.

Capacitive Coupling Proven to Upregulate Multiple Bone Morphogenetic Proteins (BMPs) 1*

BMP Expression in Response to Capacitive Coupling Stimulation

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  • The upregulation of multiple BMPs was shown to occur with capacitive coupling (CC) stimulation in as little as 30 minutes of exposure with optimal upregulation occurring at 24 hours. 1*

  • While the greatest expression of osteogenic BMPs was observed after 24 hours of CC stimulation, two to three times more upregulation was observed after just 30 minutes of CC stimulation and continued to increase in a dose dependent manner. 1*

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*Although not indicative of human clinical results, outcomes from pre-clinical research have been implicated in various models of bone repair.

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*Although not indicative of human clinical results, outcomes from pre-clinical research have been implicated in various models of bone repair.

Unique intracellular and extracelluar calcium ion activation 2*

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  1. CC Stimulates Voltage Gated Calcium Ion Channels to Allow Calcium Ions to Enter into Cell

  2. Calcium Ions Then Activate Calmodulin (Protein)

  3. Activated Calmodulin Leads to Increased Cell Proliferation

Proven, level-one clinical outcomes 3

EBI Bone Growth Stimulation

The Industry leading pioneers

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EBI pioneered the bone growth stimulation market and has been proudly advancing their mission of helping people heal to restore their daily life for 45 years.

 

  • The original bone growth stimulation company

  • Backed by proven science and an established clinical history

  • The only company with three bone growth stimulation technologies

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